CB2 (Cannabinoid-2 Receptor)
CB2 (Cannabinoid-2 Receptor) is the other very important receptor from the cannabinoid receptor family that is related to CB1. The CB2 receptor was cloned back in 1993 and it is found in different tissues than CB1. They also have a different signaling system from each other and their sensitivity to agonists and antagonists is different as well. CB2 receptors are typically found to be on white blood cells, in the spleen, and also in the tonsils. They can also be found in lesser
density in the nervous system, bones, muscles, the stomach, and the liver. CB2 receptors have been the focus of many research studies because they have the potential to relieve inflammation in the body and also display anti-cancer properties. Because the THC in cannabis can bind to both CB1 and CB2 receptors, this is what makes it cause the psychoactive effects in people.
Where CB1 is associated with anxiety, stress, paranoia, appetite, and pain, CB2 is more known to be associated with inflammation, injury to bodily tissues, improvements in metabolism, and energy balance. Scientists are actively working on ways to inhibit these receptors so that symptoms of the various disorders can be relieved. If the CB2 receptors are experiencing overactivity, it could potentially cause a lowering in the immune system and a weaker ability in healing wounds.
Because of the ability that CB2 has in the replenishing of old skin cells, it is found to be useful in skin conditions such as psoriasis and eczema. If the endocannabinoid system is not functioning properly, people usually will develop issues seen in their skin.
Use of Term
I prefer strains of cannabis that activate my CB2 receptors due to my skin conditions, and I find that it helps reduce the overall inflammation in my body.