Cannabidiolic Acid (CBDA)
Cannabidiolic Acid (CBDA) is a compound derived from cannabis and hemp. It forms into cannabidiol (CBD) when it is under exposure to heat. Decarboxylation is the process that happens when a marijuana plant is exposed to the heat or even sunlight. As a result, CBDA then turns into CBD. CBDA can be thought of as the raw form of CBD. Many topicals, capsules, and tinctures contain CBDA. Where cannabinoids like THC bind to CB1 or CB2 receptors, CBDA works a bit differently.
CBDA is known to inhibit the cyclooxygenase-2 enzyme. These enzymes are responsible for inflammation when you get an injury, so if the enzymes are blocked by CBDA, then inflammation and the pain that comes from it can then be blocked as well. There was a study done on rodents which concluded that CBDA can have an impact on serotonin levels. Serotonin has a tremendous impact in the human body that ranges from emotions, sleeping, appetite, digestion, and even motor skills.
CBDA has been studied by scientists for around a decade and research has shown that CBDA can possibly be effective alleviating nausea in patients that are undergoing chemotherapy or have other issues that are making them feel sick. CBDA has been shown to be potentially as effective to work as an anti-convulsive. In comparison to CBD, CBDA has been proven to have an effect on the 5-HT receptors and this means that humans are able to metabolize it in less time and with a lot less effort.
Many more human trials needs to be conducted in order to be able to efficiently use CBDA as an approved medical therapy. One study in 2008 showed that the molecular structures of CBDA and some anti-inflammatory medications are very similar in the way they treat inflammation.